Prograf Blood Level, (Tacrolimus, FK 506) (PROG)

Price: 35 د.ا

The normal range for tacrolimus blood levels can vary slightly depending on the laboratory and the specific patient population, but general guidelines are as follows:

– Females: 5-15 ng/mL

– Males: 5-15 ng/mL

– Children: 5-20 ng/mL

Function in the Body

Tacrolimus (Prograf) is an immunosuppressive drug primarily used to prevent organ rejection in patients who have undergone organ transplantation. It works by inhibiting the activity of T-lymphocytes, which are cells in the immune system that can attack transplanted organs.

Diseases Revealed by the Test

The Prograf blood level test is crucial in the management of patients with:

– Organ transplants: Ensuring appropriate immunosuppression to prevent rejection.

– Autoimmune diseases: In certain conditions, tacrolimus is used off-label for diseases like lupus and rheumatoid arthritis.

Symptoms Monitored by the Test

The test is used to monitor for signs of both deficiency and overdose of tacrolimus.

Symptoms of Deficiency:

– Organ rejection: This can present with symptoms specific to the transplanted organ, such as decreased kidney function in kidney transplant recipients or shortness of breath and chest pain in heart transplant recipients.

– Increased immune activity: Symptoms related to the underlying autoimmune disease may resurface.

Symptoms of Overdose:

– Kidney toxicity: Decreased urine output, swelling in the legs, increased blood pressure.

– Neurological symptoms: Tremors, headache, seizures.

– Gastrointestinal symptoms: Nausea, vomiting, diarrhea.

Diagnosis

To diagnose the appropriate levels of tacrolimus in the blood, a simple blood draw is performed. The timing of the test is critical, often done 12 hours after the last dose and immediately before the next dose (trough level). This helps to ensure the drug level remains within the therapeutic range, minimizing the risk of rejection or toxicity.

Frequently Asked Questions

1. Why is it important to monitor tacrolimus levels?

Monitoring is crucial to ensure that the drug level is high enough to prevent organ rejection but not so high that it causes toxicity.

2. How often should tacrolimus levels be checked?

Initially, levels are checked frequently (e.g., weekly). Once stable, the frequency may decrease to monthly or as advised by your healthcare provider.

3. What factors can affect tacrolimus levels?

Several factors can influence tacrolimus levels, including other medications, food interactions, and liver function. It’s important to take tacrolimus at the same time every day and in the same relation to meals to maintain consistent levels.

4. What should I do if I miss a dose of tacrolimus?

If you miss a dose, take it as soon as you remember unless it is close to the time of your next dose. Do not double up on doses. Contact your healthcare provider for specific instructions.

5. Can I take other medications with tacrolimus?

Many medications can interact with tacrolimus, either increasing or decreasing its levels. Always inform your healthcare provider about any new medications, including over-the-counter drugs and supplements.

By understanding the role of tacrolimus and monitoring its levels, patients and healthcare providers can work together to ensure the success of organ transplantation and manage autoimmune diseases effectively.

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