Cortisol PM Blood, Serum (CORPM)

Price: 15 د.ا

Cortisol, often referred to as the “stress hormone,” plays a crucial role in the body’s response to stress. The Cortisol PM Blood, Serum (CORPM) test measures the level of cortisol in the blood, typically taken in the evening when cortisol levels are at their lowest. This test is essential for diagnosing various conditions related to abnormal cortisol levels.

Normal Range

Cortisol levels can vary depending on the time of day, with higher levels in the morning and lower levels in the evening. For the CORPM test, the normal range differs by age and sex.

– Females: 2-10 micrograms per deciliter (mcg/dL)

– Males: 2-10 mcg/dL

– Children: 3-8 mcg/dL

Function in the Body

Cortisol is produced by the adrenal glands and has several vital functions:

1. Regulation of Metabolism: Helps control the body’s use of fats, proteins, and carbohydrates.
2. inflammatory Response: Reduces inflammation and helps the immune system respond to infections.
3. Blood Sugar Control: Increases blood sugar through gluconeogenesis.
4. Stress Response: Prepares the body for a “fight or flight” response.
5. Blood Pressure Maintenance: Helps maintain proper blood pressure levels.

Diseases Revealed by the Test

Abnormal cortisol levels can indicate various diseases and conditions:

1. Cushing’s Syndrome: Characterized by high cortisol levels, leading to symptoms such as weight gain, hypertension, and a rounded face.
2. Addison’s Disease: Marked by low cortisol levels, resulting in fatigue, weight loss, and low blood pressure.
3. Adrenal Insufficiency: Insufficient production of cortisol due to adrenal gland dysfunction.
4. Hypopituitarism: The pituitary gland fails to produce adequate hormones, including those that stimulate cortisol production.

Symptoms of Cortisol Imbalance

Symptoms can vary based on whether there is an excess or deficiency of cortisol.

– Symptoms of High Cortisol (Hypercortisolism):

– Weight gain, especially around the abdomen and face

– High blood pressure

– Osteoporosis

– Mood swings, anxiety, and depression

– Increased thirst and urination

– Symptoms of Low Cortisol (Hypocortisolism):

– Fatigue and muscle weakness

– Weight loss and decreased appetite

– Low blood pressure, which may lead to fainting

– Hyperpigmentation of the skin

– Cravings for salty foods

Diagnosis

The diagnosis of cortisol-related disorders typically involves a combination of blood tests, urine tests, and imaging studies. The CORPM test is often part of a broader diagnostic approach, which may include:

1. ACTH Stimulation Test: Measures how well the adrenal glands respond to adrenocorticotropic hormone (ACTH).
2. Dexamethasone Suppression Test: Evaluates how cortisol levels change in response to synthetic steroids.
3. 24-Hour Urinary Free Cortisol Test: Measures cortisol levels in the urine over 24 hours.
4. Imaging Studies: CT scans or MRIs of the adrenal and pituitary glands to detect abnormalities.

 Frequently Asked Questions

1. Why is the CORPM test done in the evening?

The evening cortisol test is done to measure the lowest levels of cortisol, helping to identify abnormal patterns that might not be evident with a morning test.

2. Can stress affect cortisol test results?

Yes, acute stress can temporarily increase cortisol levels. Chronic stress can lead to sustained high levels of cortisol.

3. How should I prepare for a CORPM test?

Follow your healthcare provider’s instructions, which may include avoiding certain medications, foods, and physical activities before the test.

4. What conditions can cause falsely elevated cortisol levels?

Pregnancy, physical stress, and certain medications (like oral contraceptives and corticosteroids) can cause elevated cortisol levels.

5. How are cortisol imbalances treated?

Treatment depends on the underlying cause and may include medication, lifestyle changes, or surgery in severe cases.

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