Vancomycin, Serum (VANC)

Price: 20 د.ا

The normal range for Vancomycin serum levels can vary slightly depending on the laboratory and specific test methods used. However, typical reference ranges are:

– Adults (Female and Male): 10-20 mcg/mL (therapeutic range for most infections)

– Children: 5-15 mcg/mL (therapeutic range can vary based on age and weight)

Function in the Body

Vancomycin is an antibiotic used to treat severe bacterial infections, particularly those caused by Gram-positive bacteria, including methicillin-resistant *Staphylococcus aureus* (MRSA). It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. The serum test measures the concentration of vancomycin in the blood to ensure it is within the therapeutic range, optimizing its efficacy while minimizing potential side effects.

Diseases Revealed by the Test

The Vancomycin Serum (VANC) test is used primarily to monitor the levels of vancomycin in patients undergoing treatment with this antibiotic. It helps in:

– Monitoring Effectiveness: Ensuring that the vancomycin concentration is high enough to effectively treat the infection.

– Preventing Toxicity: Avoiding potential toxicity by keeping serum levels within a safe range.

The test does not directly diagnose diseases but helps manage treatment for infections like MRSA and other serious Gram-positive bacterial infections.

Symptoms

Symptoms indicating the need for a Vancomycin serum test include:

– Persistent or Severe Infections: Particularly those that are resistant to other antibiotics.

– Side Effects of Vancomycin: Such as nausea, vomiting, dizziness, or skin rash, which may prompt testing to adjust dosage.

Symptoms of Deficiency and Overdose

Deficiency (Low Levels):

– Persistent or worsening infection symptoms despite vancomycin therapy.

– Increased bacterial growth or resistance, indicating inadequate drug concentration.

Overdose (High Levels):

  – Renal Toxicity: Symptoms such as reduced urine output, swelling, and elevated blood urea nitrogen (BUN) and creatinine levels.

– Ototoxicity Symptoms like hearing loss or ringing in the ears.

– Red Man Syndrome: A reaction characterized by flushing, rash, or itching, often due to rapid infusion of vancomycin.

Diagnosis

Diagnosis-related to vancomycin levels involves:

– Patient History and Symptoms: Identifying infections that require vancomycin treatment.

– Vancomycin Serum Testing: Measuring serum levels to adjust dosages for therapeutic efficacy and safety.

– Renal Function Tests: Monitoring kidney function to avoid toxicity, as vancomycin is primarily excreted through the kidneys.

Frequently Asked Questions

1. How often should the Vancomycin serum test be done?

The frequency of testing depends on the patient’s condition, treatment duration, and response. Typically, levels are checked at least once a week during therapy, or more often if kidney function is impaired or if there are signs of toxicity.

2. What if my vancomycin level is outside the normal range?

If levels are too low, the treatment may be ineffective. If levels are too high, there is a risk of toxicity. Adjustments in dosage or frequency of administration will be needed based on the test results and clinical judgment.

3. Can vancomycin levels be affected by other medications?

Yes, certain medications can interact with vancomycin and affect its levels. Always inform your healthcare provider of all medications you are taking.

4. Are there any dietary or lifestyle changes needed while on vancomycin?

Generally, there are no specific dietary restrictions with vancomycin, but maintaining good hydration is important to support kidney function.

5. What should I do if I miss a dose of vancomycin?

Contact your healthcare provider for guidance on how to proceed. Do not double up on doses to make up for a missed dose without professional advice.

By understanding the Vancomycin Serum (VANC) test and its implications, patients and healthcare providers can work together to ensure effective and safe treatment of serious bacterial infections.

Medical Laboratory Professionals’ primary duty is the patients, placing their welfare above their own needs and desires thus ensuring that each patient receives the best service and the highest quality of care according to current standards of practice. High quality laboratory services are safe, effective, efficient, timely, equitable, and patient-centered. Medical Laboratory Professionals work with all patients and samples without regard to disease state, ethnicity, race, religion, or sexual orientation. Medical Laboratory Professionals prevent and avoid conflicts of interest that undermine the best interests of patients. Learn More