Total Bilirubin

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The Total Bilirubin test measures both unconjugated (indirect) and conjugated (direct) bilirubin in the blood. Bilirubin is a yellow pigment formed during the breakdown of red blood cells and is processed by the liver for excretion in bile.

Function in the Body

• Waste removal: Facilitates elimination of heme breakdown products
• Antioxidant role: Scavenges free radicals

Normal Range

• 0.1 – 1.2 mg/dL (may vary slightly by laboratory)

High Bilirubin (Hyperbilirubinemia)

Causes:

• Liver diseases (hepatitis, cirrhosis)
• Bile duct obstruction (gallstones, tumors)
• Hemolysis (accelerated red cell breakdown)
• Genetic syndromes (Gilbert’s syndrome)

Symptoms:

• Jaundice (yellowing of skin/eyes)
• Dark urine
• Pale stools
• Fatigue, nausea, abdominal discomfort
• Itching (pruritus)

Low Bilirubin

• Deficiency is rare.
• Very low levels have been anecdotally linked to reduced antioxidant protection.

When & How to Test

• When: As part of a liver function panel or if jaundice is present
• Preparation: No special preparation or fasting required
• Procedure: Single blood draw; results typically available within 24 hours

Maintaining Healthy Bilirubin Levels

• Hydration: Adequate water intake
• Nutrition: Antioxidant-rich foods (leafy greens, citrus, turmeric)
• Lifestyle: Avoid excessive alcohol and hepatotoxic substances

Frequently Asked Questions

1. What causes high bilirubin levels?
   – Liver disease, hemolysis, bile duct obstruction, certain medications, or genetic conditions.
2. Can bilirubin be lowered naturally?
   – Yes—through proper hydration, a balanced diet, and avoiding alcohol or toxins.
3. Is high bilirubin always liver disease?
   – Not necessarily: benign conditions like Gilbert’s syndrome can cause mild elevations without liver damage.
4. Can newborns have high bilirubin?
   – Yes; neonatal jaundice is common and often resolves with phototherapy or feeding adjustments.
5. What should I do if my bilirubin is abnormal?
   – Consult your healthcare provider for further evaluation, which may include imaging or additional liver tests.

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