Immunoglobulin A (IgA), Serum

Price: 12 د.ا

Normal Range:

– Female: 70 – 400 mg/dL

– Male: 70 – 400 mg/dL

– Children: 10 – 100 mg/dL (varies with age)

Function in the Body:

Immunoglobulin A (IgA) is an antibody that plays a crucial role in the immune system. It is primarily found in mucous membranes, such as those in the respiratory and gastrointestinal tracts, and in secretions like saliva, tears, and breast milk. IgA helps protect these surfaces from infection by binding to pathogens and preventing their attachment and entry into the body.

Diseases Revealed by the Test:

– IgA Deficiency: An immune disorder where the body does not produce enough IgA, leading to an increased risk of infections, particularly of the respiratory and gastrointestinal tracts.

-IgA Nephropathy (Berger’s Disease): A kidney disorder characterized by the buildup of IgA in the kidneys, which can cause inflammation and damage.

– Celiac Disease: An autoimmune condition where IgA antibodies may react against gluten, causing damage to the intestines.

– Chronic Infections or Autoimmune Diseases: Alterations in IgA levels can be indicative of underlying conditions such as chronic infections or autoimmune diseases.

Symptoms:

IgA Deficiency:

– Recurrent respiratory infections (e.g., sinusitis, pneumonia)

– Chronic diarrhea

– Autoimmune disorders (e.g., rheumatoid arthritis, lupus)

– Allergies and asthma

IgA Nephropathy:

– Blood in urine (hematuria)

– Protein in urine (proteinuria)

– Swelling in the legs and ankles

– High blood pressure

Celiac Disease:

– Diarrhea or constipation

– Abdominal pain and bloating

– Weight loss

– Fatigue

Symptoms of Deficiency and Overdose:

Deficiency:

– Frequent infections, particularly of mucosal surfaces

– Autoimmune disorders

– Increased susceptibility to allergies

Overdose:

Typically, there are no direct symptoms of IgA overload as IgA levels are usually self-regulated. However, very high levels might be associated with underlying conditions such as chronic infections or certain cancers.

Diagnosis:

– The IgA serum test measures the amount of IgA in the blood.

– High Levels: May suggest chronic infections, autoimmune diseases, or certain types of cancer.

– Low Levels: May indicate IgA deficiency, which can be confirmed with further immunological tests and clinical evaluation.

Frequently Asked Questions:

1. What does a high IgA level indicate?

High IgA levels can be associated with chronic infections, autoimmune disorders, or certain cancers. It’s important to correlate these findings with clinical symptoms and other diagnostic tests.

      2. What does a low IgA level indicate?

Low IgA levels may suggest IgA deficiency, which can lead to frequent infections and an increased risk of autoimmune disorders. Further evaluation is often needed to determine the underlying cause.

3. How is the IgA serum test performed?

A blood sample is taken from a vein in your arm and sent to a laboratory for analysis.

4. Are there any special preparations needed before the test?

Typically, no special preparation is required. However, you should follow any specific instructions provided by your healthcare provider.

5. Can IgA levels fluctuate?

Yes, IgA levels can fluctuate due to infections, stress, or other factors. It’s important to interpret the results in the context of your overall health and any symptoms you may be experiencing.

 

 

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